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KMID : 0378019890320010069
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New Medical Journal
1989 Volume.32 No. 1 p.69 ~ p.79
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Ultrastructural Changes of Hepatocytes after Organo-phosphate(Parathion)Exposure
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Abstract
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The authors studied the ultrastructural changes of hepatocytes to clarify the mechanism of detoxication after parathion exposure.
Sprague-Dawley rats weighing 200 to 250 gm were injected with single dose of 1.5 mg/kg (1/2 L 50) of parathion intraperitoneally. And then sacrificed at the time of 1, 2, 6, 12, 24, 48 hours after injection, respectively. The control group was injected with physiologic saline.
The results obtained were summarized as follow: The toxic signs and cellular injury were most severe on the group of 2 hour after. Slow recovery phases were followed and nearly normal cellular patterns were observed after 24 hours. The injury mechanism of parathion on the liver might not be direct but indirect hypoxic injury due to respiratory failure. The major targets among the intracellular organelles were mitochrondria and RER. They revealed swelling, loss of cristae, and detachment of ribosomes. After 6 hours, fat droplets were noted and most pronounced in the group of 12 hours after. SER hypertrophy was seen after 12 hours and most striking increase was seen in the group of 48 hours after.
The results of this study suggested that major contributing organel on the detoxication of parathion in hepatocyte is SER. And recovered individuals after exposure of small amount of parathion world be more resistant than non-exposed.
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